Neocortex
1) eyeblink reflex in cats
2) Lashley's work
3) theory that long-term memories are stored in neocortex.
Focus will be on Frontal Lobes (prefrontal cortex) because they
are evolutionarily the most recent and therefore understanding their function
may lead to an understanding of what makes primates 'special' intellectually.
Dysfunction of these lobes due to vascular, genetic or traumatic reasons
produces symptoms that include various cognitive problems.
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Associating remembered facts w/i a context relative to self. This symptom
Squire (ch 7 schacter) calls 'source amnesia'. Squire suggests that
frrontal lobes provide the possibility of placing one-self autobiographically
within a particular episode. This type of memory is referred to as
episodic memory. This phenomenon of source amnesia is also seen in
the very young and the aged and can be correlated with the fact that these
areas are slow to mature and are dysfunctional in the aged.
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Another symptom of frontal lobe damage is that people are unable to make
adjustments to their environment i.e. they perseverate (possibly relevant
to obsessive/compulsive disorder). This is illustrated by testing
people using the Wisconsin Card Sorting Test.
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Impaired ability to plan. Some what seen in work done using the Wisconsin
Card Sorting Test. Also seen in patients behavior in everyday life.
Patients with frontal lobe dysfunction are unable to complete tasks that
are multifaceted or require many steps. They are easily distracted.
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Patients tend to confabulate. Impaired ability to develop associations
between facts that are both semantic as well as episodic which leads
to their making up stories. Text supplies ample evidence for this
contention. Furthermore, Moscovitch provides evidence that this phenomenon
is a problem with search, retrieval and monitoring but not storage.
This hypothesis is supported by the fact that confabulation involves premordbid
as well as postmorbid memories. Thus he suggests that, due to this
work w/patients who confabulate, the dorsal lateral frontal cortex is involved
in initiating and carrying out strategic serch of memory stores while the
ventormedial portion is involved in monitoring and checking the validity
of search results as well as holding back irrelevant responses. Within
this theory response omission occurs when the strategic search mechanism
is very badly damaged while confabulation occurs is the retreival and search
process is moderately impaired. Brought up idea of executive function.
Cell firing data in primates implicates this area in holding information.
Cells in the principal sulcus which is an area analogous to the prefrontal
region in humans will fire during the delay period of a delay matching
to sample test. This capacity suggests that the lateral frontal cortical
regions are involved in 'working memory'.